The current pandemic provides an opportunity offer we shouldn't refuse. Global alignment in regulatory processes for medicines has been slow. We should put funding and resources into refining the processes now, for the coming years of COVID management and for the next pandemic, outbreak or global emergency. It is refreshing to see WHO and ICMRA step up to the plate. They need unified support and resource-intensive investment, however. The world should examine WHO/ICMRA joint priorities, invest in labor for ICMRA and industry liaisons, and request polished organization. Priorities around well-designed clinical trials, endpoint and safety data strategies, sharing data for multi-country approvals, incorporating ICMRA regulatory agility in policies and protocols, supporting rapid response for global emergencies, transparency of trial results, strengthening public trust in vaccines, supporting the mitigation and prevention of drug shortages, COVID therapeutic surveillance,...